Sudden cardiac death has been linked to thyroid disease. Patients with thyroid levels on the higher end of normal have a significantly greater risk of sudden cardiac death, according to new research published in Circulation.
Layal Chaker, MD, MSc, research fellow in endocrinology and epidemiology at Erasmus University Medical Center, Rotterdam, Netherlands, and colleagues evaluated 10 318 patients in the Rotterdam Study with an average age of 64.7 years who underwent thyroid-stimulating hormone (TSH) or free thyroxine (FT4) measurements. Patients were nearly all Caucasian and more than 57% of the population were women.
The Rotterdam Study is a long-term evaluation of heart disease and other chronic disease in middle-aged and elderly individuals in the Netherlands.
The researchers defined euthyroidism as a value within the reference range (0.85–1.95 ng/ dL) and hypothyroidism was defined as TSH of >4.0 mIU/L and FT4 <0.85 ng/dL.
Using an age- and sex-adjusted Cox proportional-hazards model, the researchers found 261 sudden cardiac death events (3.1 per 1000 person-years); of these patients, 231 euthyroid patients experienced sudden cardiac death events.
Dr Chaker and colleagues also found patients with other factors, such as high blood pressure or high cholesterol, had an increased risk of sudden cardiac death after controlling for these factors in the analysis.
You can read the full study here:
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