Issue # 199  May 1, 2014


Welcome to KnowYourThyroid.


Today, Magdalena Wszelaki is explaining the importance of detoxing your liver for overall improved health including your thyroid function. Be sure to read to the end, so you can sign up for the free workshop Magdalena is offering.






The surprising impact of liver on hormonal balance.  

Learn how caring for your liver will free you from hormone-related symptoms such as fatigue, infertility, weight gain, mood swings and hair loss.

When someone mentions “hormonal imbalance” what comes to mind is the need to “go on the pill”, start a hormone replacement therapy or start bio-identicals. We also assume that being unbalanced is part of womanhood and little can be done about it. I want to show you otherwise.

Have you ever wondered what your liver would say to you if it had a voice?  Most livers would have a lot to moan about given half the chance.  The truth is our livers almost always suffer in silence and rarely express their stress.  When they do, it often occurs in ways which we do not associate directly with this vital organ.  So, instead of making a big fuss the liver slowly starts to tire (sluggish liver) and this can have a massive affect on our overall health.  This may sound scary but the magical factor to remember is the liver has a miraculous ability to heal and regenerate when given the right conditions.  The good news is that taking a few simple steps makes the world of difference and it is within your power to make your liver smile again.

Your liver does so much more than you imagined.

The liver is responsible for over 200 functions in the body and is the largest internal organ, weighing in at about  55oz (or 1.5 kg).  It is central to so many of the body’s functions and most people are unaware of how vital it is to good health.  Some of the major functions of the liver are:

purifying our blood (50 oz or 1.4 litres a minute),

regulating the metabolism (through bile production),

storing minerals and fat soluble vitamins, protein synthesis, glycogen storage and conversion (energy production),

cholesterol production (which is a good thing! Cholesterol, contrary to Western medicine’s believes, cholesterol necessary as it is the precursor for our steroid hormones, it manages our brain function, nerve function and hormone transportation),

parasite protection (by filtering protazoa) and…

more famously… detoxification.

Although the liver is wonderful at healing and amazing at self-recovery, it does take a great deal of abuse in our Western lifestyles.  Some of the choices can be fairly obvious (like eating non-organic food, living in a polluted area, drinking contaminated water) but many other choices (like skin care products, house cleaning products, drinking tap water or prescription medication) can create further load which we might not even be aware of. According to the EWG (Environmental Working Group), studies show that an average American is daily exposed to 200 chemical toxins and carries as many as 91 of them.

Where is all the toxicity coming from?

There are a lot of factors which affect whether the liver performs its critical functions effectively and often poor lifestyle choices can put too much pressure on this delicate organ.  Here what contributes to our toxic load:

non-organic food (think: mercury, lead, PCBs and over 130 pesticides)

air pollution (a long list)

tap water (think: fluoride, chlorine, PCBs, mercury, lead, parasites)

skin care products (think: phthalates, BPA, triclosan, parabens)

house hold cleaning products (think: triclosan, phthalates, parabens)

medications; both recreational and prescription, including commonly-used ones like corticosteroids, tetracycline and aspirin

plastics (think: BPA, PFOA)

cookware like non-stick pans (think: PFOA)




Our body is designed to excrete them. We have a few detoxification organs, namely: skin, lungs, kidneys, digestive tract and, of course, the liver. They are all capable to perform the beautiful job of freeing us from these toxins – the challenge is: when the load is higher than what they can handle, this is when toxicity takes a toll on us.

Early signs of liver problems. 

So what symptoms can we expect to experience when our liver is tired?  We commonly hear about cirrhosis (permanent scarring) of the liver and the increase in liver disease in the Western world. It’s completely possible to determine them by doing the right blood work and testing for markers like aspartate aminotransferase (AST or SGOT) and alanine aminotransferase (ALT or SGPT). The challenge is: by the time they are raised, much of the liver damage has already been done.

It’s key to be proactive, educated and step into a preventative mode. How often do you hear about the common symptoms which are associated with liver fatigue as a result of a toxic or stressful lifestyle?  You certainly won’t be hearing about them from your doctor.  Here are some common symptoms which may be related to sluggish liver detoxification and function:

Hormonal imbalance

Intolerance to HRT (hormone replacement therapy)

Severe menopausal symptoms


Estrogen Dominance

Mood Swings

Blood Sugar Problems

Sugar Cravings


Type 2 Diabetes

Energy slumps

Waking in the night

Immune dysfunction

Allergies/ Skin rashes

Chemical sensitivities (think: someone who can’t stand fumes or perfumes)

Chronic Fatigue/Fibromyalgia

Frequent illness

Nervous System


Anger and irritability

Foggy brain


Frequent headaches

Digestive Problems

Gall stones

Intolerance to fat

Sensitivity to alcohol and/or caffeine

Acid reflux

Bloating or constipation

Irritable bowel syndrome

External signs

Furry tongue

Bad breath

Acne and rosacea

Yellow, red or itchy eyes


Brown spot on hands, back and face

Abnormal metabolism of fats (lipids)

Abnormal level of fats in the blood, e.g. high LDL (“bad cholesterol”) and reduced HDL (“good cholesterol”)

Elevated triglycerides

Blocked arteries leading to hypertension, heart attacks and strokes

Fatty liver


The connection of the liver to hormonal health.

Most of us know that our liver is responsible for processing alcohol, but there is so much more. Let’s just look at its connection to our hormones.

Excretion of metabolized or “used” hormones

The liver Phase Two detoxification phase (see below) excretes metabolizes hormones – this means hormones that have been “used” by the body to make space for new ones. A sluggish liver won’t be getting rid of the “used thyroid hormone” to make space for new ones – this further amplifies hormone-related symptoms.  This is a fact that most women have no knowledge of and have a big “aha” moment. After all, which doctor tells us to detox our liver for hormonal wellbeing?

Conversion of T4 to T3 thyroid hormone. 

If you are having a thyroid problem, you need to know that your liver (and the digestive tract) is where the conversion of the T4 hormone happens to T3. What many people do not realize is that T4 is an inactive hormone and T3 is the active or bioavailable hormone which our body cell receptors get to use. People who are on Synthroid (or any other brand of thyroxine) are highly dependent on the function of the liver; Synthroid is a synthetic T4 and it therefore needs a well functioning liver to produce the T3 hormone.

Evacuation of xenoestrogens, or synthetic estrogens.  

Xenoestrogens are chemical compounds found in most commercial skin care products, house cleaning products, cook ware, etc. It is nearly impossible to eradicate them from our lives if you live a normal life. The problem with xenoestrogens is that they act like estrogen (so the body gets confused that we have sufficient estrogen) when in fact, they do not deliver the effect of real estrogen. Our liver is responsible for the excretion of xenoestrogens from the body. An impaired liver will struggle to do so.

Phase One and Phase Two of liver detoxification. 

The liver’s detoxification method includes two phases which are referred to as Phase One and Phase Two.

Phase One is known as oxidation and Phase One as conjugation. In Phase One, the liver uses oxygen and enzymes to burn toxins. This process is called oxidation as it makes the toxins more soluble in water so they can be more easily excreted from the body by the kidneys and the liver. Most environmental toxins are fat-soluble to start with, and therefore difficult or impossible to eliminate without the liver’s help. Did you know that the chemicals produced in Phase One are more toxic than those which originally entered the body?!

This phase of liver detoxification is inhibited by nutritional deficiency, toxic exposure and medications such as acetaminophen (brand name Tylenol), alcohol consumption, and low protein intake that deplete glutathione which is needed for acetaminophen detoxification.

To free itself of toxins produced by Phase One detoxification, the liver performs a Phase Two called conjugation. In this phase, oxidized chemicals are combined with sulfur, specific amino acids or organic acids, and then excreted in bile and urine.

Both phases are dependant on vital substances which are required to activate the catalyst for toxin conversion and they must work in balance so that no harmful toxins are left to circulate.

There are six pathways in Phase Two and each one is responsible for converting a different set of substances (e.g. estrogen, thyroid hormones, heavy metals, histamine, phenol, salicylates, biliruben, nicotine, bacterial toxins, caffeine).  The six pathways are called:

1. Amino Acid Conjugation pathway

2. The Glutathione pathway

3. The Sulphation (sulfation) pathway

4. The Methylation pathway

5. The Glucoronidation pathway

6. The Acetylation pathway.

Methylation and sulphatation pathways explained.

For an example of how these pathways work let’s look at the methylation pathway in more detail.  This allows methyl groups to pass through the liver and out of the body safely.  This pathway detoxifies estrogen, dopamine, histamine and heavy metals.  To support this pathway we can increase our intake of choline (avocados/eggs/non-GM soy lecithin) and B vitamins.

The sulphation pathway detoxifies excess neurotransmitters, steroids, thyroid hormones, phenol and excess bile acids.  This pathway is often burdened by frequent use of non steroidal anti inflammatory drugs (NSAIDS).  We can support this pathway through an increase in high sulphur foods (e.g. egg yolk, broccoli, onion or MSM).

If Phase Two is not working effectively then the highly toxic chemicals formed in Phase One cannot be converted and this can cause a lot of toxicity issues in the body such as tissue damage or disease.  It may also cause excess hormones to circulate through the bloodstream instead of being excreted and this can lead to hormonal imbalances which may affect the thyroid gland or our estrogen levels.

Healing Powers of the Liver and Diet. 

The most magical point to remember when we learn about the liver, is how effectively it can rebuild itself.  By giving it the right tools nutritionally and following a lifestyle plan that avoids nasty environmental toxins (which confuse and hinder the liver), we can literally regenerate this wonderful organ.

By detoxifying the body and giving it the right nutritional tools, your liver’s functions may be restored to full health.  Foods and herbs which support liver healing and detoxification can be used to make dramatic changes to symptoms associated with a sluggish liver and give long lasting healing effects.

About the Authors and Hormones Detox FREE Online Workshop.

The authors of this article, Magdalena Wszelaki (certified nutrition coach) and Josie Lincoln (nutritionist, UK and detox expert), are hosting a Free Online Hormones Detox WORKSHOP on May 10th at 9am PST titled “10 Toxins Impacting Your Hormones” – designed to help understand the interplay between toxins and the hormones and how to live a toxins-free life pragmatically and on a budget.

Click Here for the FREE WORKSHOP!